Controlled-Potential Electromechanical Reshaping of Cartilage


Bryan M. Hunter, Jeremy Kallick, Jessica Kissel, Maya Herzig, Cyrus Manuel, Dmitri Protsenko, Brian J. F. Wong, and Michael G. Hill. 2016. “Controlled-Potential Electromechanical Reshaping of Cartilage.” Angewandte Chemie International Edition, 55, 18, Pp. 5497-5500. Publisher's Version


Abstract An alternative to conventional “cut-and-sew” cartilage surgery, electromechanical reshaping (EMR) is a molecular-based modality in which an array of needle electrodes is inserted into cartilage held under mechanical deformation by a jig. Brief (ca. 2 min) application of an electrochemical potential at the water-oxidation limit results in permanent reshaping of the specimen. Highly sulfated glycosaminoglycans within the cartilage matrix provide structural rigidity to the tissue through extensive ionic-bonding networks; this matrix is highly permselective for cations. Our studies indicate that EMR results from electrochemical generation of localized, low-pH gradients within the tissue: fixed negative charges in the proteoglycan matrix are protonated, resulting in chemically induced stress relaxation of the tissue. Re-equilibration to physiological pH restores the fixed negative charges, and yields remodeled cartilage that retains a new shape approximated by the geometry of the reshaping jig.
Last updated on 09/04/2018